![]() It was characterized by a 130562 bp multi-replicon plasmid IncFII/IncFIA/IncFIB (pVSI_NDM-5) enclosing two main antibiotic resistance islands: (i) ARI-I, 10030 bp in size, carried genes coding for β-lactam- ( bla OXA– 1, bla CTX–M– 15), fluoroquinolone/aminoglycoside- ( aac(6′)-lb-cr) and phenicol- resistance ( catB3), (ii) ARI-II, 15326 bp in size, carried genes coding for sulfonamide- ( sul1), β-lactam- ( bla NDM– 5, bla TEM– 1 B), phenicol- ( catB3), trimethoprim- ( dfrA17), antiseptic- ( qacEΔ 1), and aminoglycoside- ( aadA5, rmtB) resistance. One strain (5P), belonged to sequence type ST405/ST477 (according to Pasture/Oxford schemes) and serotype O102:H6. The above microorganisms were collected in the same Desenzano hospital (Northern Italy) where the bla NDM– 5 gene was detected for the first time in Italy 3 years ago. 4Clinical Microbiology Laboratory, “AO Desenzano del Garda,” Brescia, ItalyĪim of this study was to genetically characterize two carbapenemase-producing Escherichia coli strains obtained from a pediatric patient affected by diarrhea, expressing OXA-181 and/or NDM-5 type enzymes.3Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.2Department of Microbiology, Faculty of Medicine in Pilsen, University Hospital in Pilsen, Charles University, Pilsen, Czechia.1Department of Clinical Surgical Diagnostic and Pediatric Sciences, Unit of Microbiology and Clinical Microbiology, University of Pavia, Pavia, Italy.Cyclic AMP, another nucleotide, is involved in regulating many aspects of cellular metabolism, such as the breakdown of glycogen.Vittoria Mattioni Marchetti 1, Ibrahim Bitar 2,3*, Alessandra Mercato 1, Elisabetta Nucleo 1, Annalisa Bonomini 4, Palmino Pedroni 4, Jaroslav Hrabak 2,3 and Roberta Migliavacca 1 The breaking of the phosphate bonds in ATP releases great amounts of energy that are consumed in driving chemical reactions or contracting muscle fibres. In certain vital metabolic processes, AMP combines with inorganic phosphate to form ADP (adenosine diphosphate) and then ATP. Nucleosides themselves rarely participate in cell metabolism.Īdenosine monophosphate (AMP) is one of the components of RNA and also the organic component of the energy-carrying molecule ATP. Nucleosides are similar to nucleotides except that they lack the phosphate group. The most common nitrogen bases are the pyrimidines (cytosine, thymine, and uracil), the purines (adenine and guanine), and the pyridine nicotinamide. The nitrogen-containing bases of nearly all nucleotides are derivatives of three heterocyclic compounds: pyrimidine, purine, and pyridine. Several nucleotides are coenzymes they act with enzymes to speed up (catalyze) biochemical reactions. The nucleotide adenosine triphosphate (ATP) supplies the driving force of many metabolic processes. In the two families of nucleic acids, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), the sequence of nucleotides in the DNA or RNA codes for the structure of proteins synthesized in the cell. Nucleic acids are poly nucleotides-that is, long chainlike molecules composed of a series of nearly identical building blocks. SpaceNext50 Britannica presents SpaceNext50, From the race to the Moon to space stewardship, we explore a wide range of subjects that feed our curiosity about space!.Learn about the major environmental problems facing our planet and what can be done about them! Saving Earth Britannica Presents Earth’s To-Do List for the 21st Century.Britannica Beyond We’ve created a new place where questions are at the center of learning.100 Women Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians.COVID-19 Portal While this global health crisis continues to evolve, it can be useful to look to past pandemics to better understand how to respond today.Student Portal Britannica is the ultimate student resource for key school subjects like history, government, literature, and more.This Time in History In these videos, find out what happened this month (or any month!) in history.#WTFact Videos In #WTFact Britannica shares some of the most bizarre facts we can find.Demystified Videos In Demystified, Britannica has all the answers to your burning questions.Britannica Explains In these videos, Britannica explains a variety of topics and answers frequently asked questions.Britannica Classics Check out these retro videos from Encyclopedia Britannica’s archives. ![]()
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